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Corresponding Author: X Du, [email protected] Authors: X

2.2 Underlying role of oxidative stress in neurodegeneration A large body of evidence demonstrates a particular susceptibility of neurons to ROS because of their distinctive characters: High energy demands, high oxygen consumption, high levels of iron, polyunsaturated fatty acids and, in particular, low anti-oxidative protection [8]

We acknowledge support from a Dreyfus Foundation award (MPL), the Philomathia Foundation (MPL), an NSF CAREER award 2046159 (MPL), a McKnight Foundation award (MPL), a Simons Foundation Award (MPL), a Moore Foundation Award (MPL), a Brain Foundation Award (MPL),), a Heising-Simons Fellowship (MPL), and a Polymaths Award from Schmidt Sciences, LLC (MPL)