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Animal toxicology signals Two animal findings reviewed by FDA are worth tracking even if they did not surface clinically

MDM2 mediates the ubiquitin-dependent degradation of SPY1, resulting in a downregulation of SPY1 expression, which in turn upregulates the expression of ALOX15 and growth differentiation factor 15 (GDF15), while decreasing the levels of GCH1, GPX4, and GSH