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These herbs contain bioactive compounds, including flavonoids, polyphenols, alkaloids, terpenoids, and saponins, which contribute to enhancing insulin secretion and improving glucose metabolism ( 2.1.2.2 Pancreatic -cell protection and -glucosidase inhibition Formulations like the Shenqi compound (SQC) have been shown to lower blood glucose, enhance insulin sensitivity, and protect pancreatic -cells by alleviating oxidative stress and inflammation, while reducing -cell apoptosis and senescence ( 2.1.2.3 Management of obesity and related metabolic risks Obesity and metabolic syndrome, significant contributors to T2DM, are addressed in TCM through a comprehensive approach that integrates herbal remedies, lifestyle adjustments, acupuncture, Tuina massage, Tai Chi, and dietary recommendations

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Like H 2 O 2 , the neurotoxic 6-OHDA also damages mitochondrial membrane protein complex I, leading to burst ROS (HO and H 2 O 2 ) generation (Cores et al., 2023

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