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Sleep Medicine Reviews, 22, 23-36

Among them, the EPIC algorithm is based on RNA-seq data and utilizes reference gene expression profiles to estimate the relative proportions of immune and cancer cells within the tumor microenvironment

Losing the glutamate at position 3 sharply reduces its binding to IGF-binding proteins, which is why in cell culture it is reported to be roughly ten times more potent than intact IGF-1 at driving cell proliferation and hypertrophy [1]