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Description

The ALOX family can mediate PUFAs peroxidation to generate AA/AdA-PE-OOHs, thereby triggering ferroptosis (Lei et al., 2019)

Additional research confirmed TB-500s actin-sequestering mechanism promotes cell motility at concentrations as low as 0.11.0 g/mL in cell culture models

Altogether, this second hit, comprising NS3hSL1NS5B, may represent a priming complex, in which interactions between the three partners would position the 3end of the (+) strand to be presented to the RNA binding groove of NS5B (Fig