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(1997) The safety profile of GH replacement therapy in adults

Subsequently, it was found that co-inactivation of DHODH and mitochondrial GPX4 led to mitochondrial lipid peroxidation and that BQR treatment significantly increased the intracellular CoQ10/CoQH2 ratio [103], suggesting that DHODH inhibits mitochondrial lipid peroxidation by reducing CoQ10 to CoQH2 in concert with mitochondrial GPX4

158(7):23092318 Sun GW, Kobayashi H, Suzuki M, Kanayama N, Terao T (2003) Follicle-stimulating hormone and insulin-like growth factor I synergistically induce up-regulation of cartilage link protein (Crtl1) via activation of phosphatidylinositol-dependent kinase/Akt in rat granulosa cells

This results in sustained release, better tissue targeting, stronger mitochondrial protection, and improved redox balance