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P.et al (2025)

To estimate the CY 2026 proposed hospital outlier payments (90 FR 33841), we inflated the charges on the CY 2024 claims using the same proposed charge inflation factor of 1.1118 that we used to estimate the IPPS fixed-loss cost threshold for the FY 2026 IPPS/LTCH PPS proposed rule (90 FR 18434 through 18436)

However, for othersparticularly those with a more severe deficiency or underlying health conditionsit may take up to a week or even several weeks to experience significant changes

[1] The volumes of air typically present in injection pens (often just a few small bubbles) are far below any threshold that could cause harm via the subcutaneous route