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doi: 10.3389/fphar.2026.1796921 Received 28 January 2026 Revised 23 April 2026 Accepted 27 April 2026 Published 14 May 2026 Volume 17 - 2026 Edited by Arindam Kuila, Banasthali University, India Reviewed by Haiyun Xu, Wenzhou Medical University, China Lei Li, Second Military Medical University, China Updates Copyright 2026 Gao, Luo, Chen, Mi, He, Shang, Sui and Zheng

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32 Over five consecutive days (day 15), mice underwent fear conditioning, where they learned to associate a repeated unconditioned stimulus (a single electric foot shock per day