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gasseri prevented dexamethasone (DEX)-induced muscle atrophy by stimulating myogenesis and protein synthesis through activation of the IGF-1-PI3K/AKT/mTOR pathway, reducing protein breakdown via FOXO-mediated modulation of the ubiquitin-proteasome pathway (UPP) and autophagy lysosomal pathway (ALP)

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Friedmann AngeliJSchneiderMPronethBTyurinaYTyurinVHammondVet alInactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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doi: 10.1152/ajpendo.00258.2006 153 EckertSMHiranoTLeedomTATakeiYGrauEG

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Furthermore, AgNPs may circumvent chemoresistance mechanisms, such as drug efflux or DNA repair upregulation, through multifaceted actions including ROS generation, mitochondrial dysfunction, and signaling pathway interference

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