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Clinically, the concept of cold acclimation may provide a useful framework for understanding the vulnerability of distal hypothermic tissuessuch as the hands, feet, and nasal mucosain cold environments, as well as the increased risk of infection associated with therapeutic hypothermia

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However, daily administration of high dose IVC to rodents with implanted prostate tumor cells showed decreased tumor growth and lung metastases (Pollard et al., 2010)

In vitro experiments confirmed that miR-374 significantly suppressed PGC-1 expression in -cells and hepatocytes by binding to its 3-UTR