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The global burden of low back pain: Estimates from the Global Burden of Disease 2010 study

Excessive methionine intake in the presence of inadequate intake of folic acid , vitamin B6 , and vitamin B12 , can increase the conversion of methionine to homocysteine , a substance linked to heart disease and stroke

doi:10.1016/j.bjorl.2015.04.016

Methylcobalamin is produced synthetically via microbial fermentation and chemical synthesis, yielding pharmaceutical-grade vitamin B12 in the active coenzyme form