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We chose P90 as the time of investigation, because this is a symptomatic stage with profound CSMN loss, and it coincides to the disease stage, when patients show symptoms and TDP-43 pathology begins to occur

(See ch31etb0.1 for designations of various eosinophil factors.) Among the products of eosinophils that are most damaging to the host are the specific granules cationic proteins