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The observed differences in ROS accumulation between strains led us to investigate potential changes in other antioxidant functions that could potentially compensate for the loss of GSH2 in the mutants

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Thus, our findings suggest that inflammatory caspases could be important novel therapeutic targets in the comprehensive treatment or prevention of both neovascular and nonexudative AMD, and indicate that targeting inflammatory caspases may inhibit AMD more potently than when targeting Nlrp3 or IL1 signaling