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Consideration should be given to stopping valproate in patients who develop hypothermia, which may be manifested by a variety of clinical abnormalities including lethargy, confusion, coma, and significant alterations in other major organ systems such as the cardiovascular and respiratory systems

A.SappP.HentatiA.et al

TRPM2 TRPM2 has MHR1-4 with the IQ-motif at the large N -terminus, conserved six transmembrane segment (S1-S6) regions, and a pore-forming loop domain between S5 and S6 as well as the C -terminus composed of the TRP helix containing TRP box1 and TRP box2, a coiled-coil domain (CCD), and a unique enzymatic NUDT9 homology (NUDT9-H) domain (Figure 1)

doi: 10.3390/ani11040979 197 SimonsAAlhanoutKDuvalRE