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Clinical studies indicate that milk thistle extract has the potential to reduce blood glucose levels and glycated hemoglobin (HbA1c) in individuals diagnosed with type 2 diabetes, who are currently undergoing treatment with antidiabetic medications, should take it with caution [49, 53, 151]

Also, BPC 157 (in aortal ring) induced vasodilatation (even when endothelium is removed) and regulated vasomotor tone through BPC 157specific activation of the SrcCaveolin-1ensdothelial NOS (eNOS) pathway (Vukojevic et al., 2018

doi:10.1016/j.arr.2024.102575 69

The BSO-induced increase in glutamate was accompanied by an increase in mEPSC frequency (Fig