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But according to what hes observed in his clinical practice, some people may not notice the same response particularly if theyve been off the medication for a longer period, and were not sure why, but it may be similar to the way yo-yo dieting can negatively impact metabolic health and contribute to progressive weight increase. Needless to say: any medication could have significant impact on your health and wellbeing, so you should consult medical professionals before making any decisions.