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However, total hormone metabolite levels were not changed but in fact showed a tendency to be higher in the COC users (Table 2)

Among the assays used in this study, TR-FRET Thyroid Receptor alpha Coactivator Assay (Invitrogen, Cat PV4587) is used for detecting the interactions between MH and THR 92 , TR-FRET PPAR Competitive Binding Kit (Invitrogen, Cat PV4894) is used to evaluate the interactions between MH and PPAR 93 , and cAMP Detection Kit (Cisbio Cat 62AM4PEJ) 94,95 is used for identifying the interactions between MH and Beta3 (Supplementary Table 15)

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Notably, endogenous cellular clocks drive the rhythmic expression of genes