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(1) For the cell to migrate forward, focal adhesions bind to integrins and engage the ECM at the leading edge of the fibroblast

nist.gov/srm/srm-definitions National Institute of Standards and Technology

Children with high excretion of toxic metals (arbitrarily defined as above Doctor's Data reference range, defined as the top 95% for typical children who are not undergoing chelation therapy) were allowed to continue on to Phase 2

Nevertheless, the precise mechanism underlying the selectivity of elesclomol is unclear, and thus further research is warranted to determine whether this selectivity can be leveraged to develop other Cu ionophores for the treatment of MI