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Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling

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The demonstration of phosphorylation of GCL using cultured hepatocytes suggests phosphorylation-dephosphorylation may be an important physiologic regulator of GCL

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Hence, the intracellular redox state, which is characterized by the levels and ratios of oxidized (GSSG) and reduced (GSH) glutathione, is regarded as a significant indication of the cellular health (Lu 2013)

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