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Moreover, excessive fission disrupts mitochondrial membrane potential, causes mitochondrial damage, and impairs both cellular energy metabolism and iron homeostasis, further sensitizing cells to ferroptosis [56]

Mechanistically, lipopolysaccharide (LPS)-induced lung injury was less severe and had less neutrophil infiltration and endothelial exudation in sphingosine kinase (SPK)1-/- mice compared to wild type (WT) mice, with decreased numbers of inflammatory cells in theBAL