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Although the causal relationship between smoking and the pathogenesis of AA has not been fully established, cigarette smoke has been shown to promote the production of proinflammatory cytokines while decreasing levels of anti-inflammatory cytokines (Dai et al., 2020)

doi: 10.1177/1559325819891008 70 PawlikTMKeyomarsiK

Upregulation of cytosolic Ca 2+ activates calcium/calmodulin-dependent protein kinase II (CAMKII), leading to aberrant NF-B signaling and downstream expression of PD-L1 58

Maintenance therapy with tumor-treating fields plus Temozolomide vs Temozolomide alone for glioblastoma: a randomized clinical trial