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In addition, copper is also involved in the binding of HIF-1 to the hypoxia response element (HRE) sequence of target genes, which requires the copper molecular chaperone CCS, and activates EMT-related genes such as snail family transcriptional repressor 1 (SNAIL1), twist-related protein 1 (TWIST1), snail family transcriptional repressor 2 (SNAIL2), zinc finger E-box-binding homeobox 1 (ZEB1), zinc finger E-box-binding homeobox 2 (ZEB2), and E12/E47 (101)

Treatment Protocol Research Limitations Moderate sample size (n=45)

Ten of the most common cruciferous vegetables eaten by people, known colloquially in North America as cole crops [1] and in the UK, Ireland and Australia as brassicas , are in a single species ( Brassica oleracea )