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Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82

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Together with enzymes like glutathione peroxidase (GPx) and glutathione reductase (GR), it plays a vital role in the body's antioxidant defense system, helping maintain cellular balance and protect against oxidative stress