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For treating a deficiency, injections are usually given frequently at the start, for example, several times per week or every other day for a couple of weeks, to quickly build up body stores

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Consistent with the hypothesis that other angiogenic factors maintain VEGF-independent vessels, pharmacologic intervention with a broad spectrum anti-angiogenic antagonist (suramin), a vascular disrupting agent (combretastatin), or a combination of VEGF and Notch pathway inhibitors reduced the established networks

Cloudiness, particles, or unusual coloration indicate contamination or degradation