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Bhattacharya and Gupta 2013

Signs and symptoms include (but are not limited to): Extreme tiredness (fatigue) Tiredness / lack of energy Pale skin Numbness and / or tingling (paraesthesia) Feeling faint Noticeable heartbeat (palpitations) Feeling short of breath Loss of appetite Ringing in your ears (tinnitius) Unintended weight loss Changes in your vision A yellow tinge to the skin Depression Irritability Changes in the way you feel, behave, and think ('brain fog') A decline in mental function, such as changes to your memory, judgement and understanding (dementia) How long do B12 injections last

The liver is incredibly efficient at breaking things down, which can significantly reduce the amount of the active compound that ultimately becomes available

Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response