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Specifically, hydrogen bonding between S778 and H701 correctly positioned the imidazole ring of H701 to form a hydrogen bond with the hydroxyl group on the D-ring to form a hydrogen bond with H701, whereas A877 was able to form a close Van der Waals contact with the D-ring of 9-fluorocortisol

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Since L-dopa is converted to dopamine in the CNS and the peri phery, peripheral conversion and systemic effects can be reduced by combining L-dopa with carbi dopa (a peripheral decarboxylation inhibitor), which does not cross the bloodbrain barrier

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