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It has been suggested that inflammatory cells have an impact on cancer development by increasing the invasive capacity, angiogenesis, and motility of tumour cells (Coussens and Werb, 2002)One paper evaluating metallothionein expression in FISS, demonstrated an association between Ki67 index (a marker of cell proliferation) and tumour grade and inflammatory score in FISS, suggesting that inflammation plays an important role not only in pathogenesis but also in tumour progression (Mikiewicz et al., 2023)