Disclosures: Cara Mack: Nothing to Disclose, Alexander Miethke: Mirum Pharmaceutical Inc: Grant/Research Support, Mirum Pharmaceutical Inc: Consultant, Ipsen: Speaking and Teaching, Kieran Hawthorne: Nothing to Disclose, Lisa Henn: Murata Vios: Consultant, Simon Horslen: Nothing to Disclose, Shika Sundaram: Nothing to Disclose, Estella Alonso: Nothing to Disclose, Nitika Gupta: Nothing to Disclose, Binita Kamath: Mirum: Consultant, Mirum: Grant/Research Support, Albireo/Ipsen: Consultant, Albireo/Ipsen: Grant/Research Support, Audentes: Consultant 2353 OBETICHOLIC ACID FOR PRIMARY BILIARY CHOLANGITIS IN THE PREVENTION OF CLINICAL EVENTS: A MODELING STUDY USING REAL-WORLD DATA Zobair Younossi 1 Alexandra Ellis 2 Jackie Lee 3 Leona Bessonova 4 Radhika Nair 4 Elizabeth Potente 4 Robert Gish 5 , 1 The Global Liver Council, Center for Outcomes Research in Liver Disease, Washington, DC, USA, 2 Stratevi, Boston, Massachusetts, USA, 3 Stratevi, Santa Monica, California, USA, 4 Intercept Pharmaceuticals, Morristown, New Jersey, USA, 5 Robert G
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It therefore appears that the TS pathway gradually evolved from early eukaryotes like Giardia and Entamoeba to intracellular Apicomplexans like Plasmodium to a fully functional pathway in Kinetoplastids like Trypanosoma
