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Interestingly, when we treated the samples with the deubiquitinase USP7, the higher molecule species were only partially reduced, indicating the presence of a mixture of both polyubiquitinated populations and membrane protein aggregates (Supplemental Figure 3)

When injected into the tumor, this strain has been shown to increase the concentration of L-arginine within the microenvironment, leading to increased infiltration of tumor-infiltrating T cells, sustained effector T-cell functions, increased tumor-specific T-cell memory formation, and enhanced efficacy of PD-L1-blocking antibodies

To further our understanding of primary cilia's function in CCA, we investigated whether the loss of primary cilia affects DNA damage response (DDR) and DNA repair processes

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