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Under normal conditions, the tissue concentrations of Mn in humans are 415 mg/L, 0.150.46 mg/kg, 1.21.3 mg/kg, ~1.04 mg/kg, ~1 mg/kg, and ~0.98 mg/kg in the blood, brain, liver, pancreas, bone and kidneys, respectively 18 (Fig

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Additionally, SLC7A11-mediated cystine uptake induces metabolic vulnerabilities, including glucose and glutamine dependencies, creating potential therapeutic targets for inducing ferroptosis in cells by disrupting their redox balance and metabolic homeostasis (Koppula et al., 2021)