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Insights 19 , 26331055241252632 (2024)

It signals metabolic status from mitochondria to the body systemically, making it relevant to aging biology and metabolic disease research in ways distinct from tissue-growth peptides

Ferroptosis is associated with various diseases, including (neuro)degenerative diseases, ischemia-reperfusion injury, acute kidney injury, and cancer

Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, Chalasani N, Dasarathy S, Diehl AM, Hameed B, Kowdley KV, McCullough A, Terrault N, Clark JM, Tonascia J, Brunt EM, Kleiner DE, Doo E (2015) Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial