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doi: 10.3389/fnins.2025.1671955 Received 24 July 2025 Revised 10 December 2025 Accepted 16 December 2025 Published 13 January 2026 Volume 19 - 2025 Edited by Fangchen Gong, Shanghai Jiao Tong University, China Reviewed by Al-Shaimaa Faissal Ahmed, Minia University, Egypt John Sieh Dumbuya, Affiliated Hospital of Guangdong Medical University, China Updates Copyright 2026 Li, Wang, Ma, Peng, Wang, Wang, Li and Wang

It should be noted, however, that while retatrutide shows promise as a weight-loss therapy for adults, its use is not currently approved for children and adolescents

Because of that, it is important to be precise

Affinity for the unphosphorylated peptide was strongly reduced ( K d = 81.0 4.5 M), while mutation of the conserved R3552 to alanine abrogated the binding to both peptides (Fig