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Fan HJ, Tan ZB, Wu YT, Feng XR, Bi YM, Xie LP, et al

Programmed death of cardiomyocytes in cardiovascular disease and new therapeutic approaches

14 revealed that the PMI and PTK hydrogels did not trigger obvious inflammatory reactions, and no inflammation cell accumulation was detected, which should be safe for in vivo applications

On this basis, the designed Gi-F-CAA with assembly enhanced binding (AEB) effect demonstrated substantial inhibition of GPX4 activity by the formation of self-assembled Gi-F nanoparticles, which augmented the oxidative stress of Fenton reaction induced by FeTCPP, leading to remarkably enhanced tumor ferroptosis