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Inclusion criteria Systematic reviews, meta-analyses, randomized controlled trials (RCTs), longitudinal observational studies No clinical signs or symptoms of dementia at onset of study Study must report onset of dementia, Alzheimer disease (AD), or cognitive decline as an outcome measure N 100 Observational period 2 years or longer Exclusion criteria Cross-sectional studies, case series, case reports Non-English studies Institutionalized subjects (inpatients) Outcomes of interest Onset of dementia or Alzheimer disease Change in cognitive function Question 2

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Also, whilst not explored here it is possible that sepiapterin treatment increased the infiltration of immune cells into the ischaemic retina

1998;62(Pt 6):48190