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Specifically, it is thought that people with histamine intolerance dont produce enough diamine oxidase (DAO), the enzyme responsible for breaking down histamine in the intestines

437 A pragmatic, open-label trial revealed that PD patients randomly assigned to initial treatment with levodopa experienced small but permanent benefits after 7 years compared with patients treated with MAO-B inhibitors or dopamine agonists, which was specifically shown by a 1.8-point improvement (95% CI, 0.53.0

Patients can get better with an individualized targeted approach to heal the immune system

The metabolic byproduct phosphoenolpyruvate (PEP) can act as an antioxidant to prevent ROS-mediated cell apoptosis (180)