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10.1016/j.jnutbio.2014.03.007 38 DomicianoT

Although our experimental approach is not designed to study whether replication of pre-existing -cells also plays a role in the formation of new islets 13 , the treatment of mPSs with THR-123 within microfluidic chips in vitro exposed the initial stages of -cell transdifferentiation from ducts in real time, as well as the acquisition of glucose responsiveness by some of these cells as determined by Ca 2+ imaging