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In addition, Gln/Glu was significantly decreased (t = -2.318, P = 0.024) in the ID group compared with the HC group ( Supplementary Figure 1 )

In that paper, the researchers used TNF antagonists combined with IKE to induce ferroptosis of RA-FLSs, which reduced cartilage and bone damage in CIA mice, and they also used an IL-6 antagonist and a TGF- antagonist to confirm the ferroptosis-regulating function of these two cytokines (39)