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Protoplasmic astrocytes may accumulate and remove -synuclein, thus exercising neuroprotection 211 , although overload with -synuclein may cause mitochondrial damage while aggregated -synuclein may spread through astrocytic syncytia 212,213

It is believed that the first 2 years of life are crucial for the development of the immune system and the formation of the gut microbiome (156)

) Summary and Conclusions Genetic variation in folate metabolism has emerged as a critical area of investigation, not only for its role in rare hereditary disorders but for its far-reaching implications in common, multifactorial conditions such as cardiovascular disease, birth defects, cancer, and neurodevelopmental disorders

Similar content being viewed by others Background Autism is a severe developmental disorder which involves social withdrawal, communication deficits, and stereotypic/repetitive behaviors