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A third widely-cited paper (McCoy 2013, PMID 23055539) the source of the often-repeated "seven orders of magnitude more potent than BDNF" line carries a 2021 Expression of Concern

Toxicity appears low, but long-term human safety is unknown

Tendon and ligament repair: Animal studies demonstrate accelerated healing of tendons and ligaments, which explains its popularity for joint and connective tissue injuries