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Cholesterol is then converted to PREG and its steroid metabolites, including PregS, cortisol, corticosterone, DHEA, and ALLO (313, 314)

This is not a fringe compound

A preclinical pilot study in human patients with chronic pain episodes found, that DSIP significantly reduced pain perception, also improved mood by reduction of depressive states, and that it may potentially be of interest for research into physiological addiction on pain medications, as it was observed to reduce withdrawal symptoms that occurs after discontinuation of long-term analgesic treatment

Mechanistically, we propose that GDF11 stimulates autophagy via inhibition of mTOR