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It is not the same as sterile water for injection (which contains no preservative) and is not intended for large-volume infusion

Clinicians should select the appropriate formulation (e.g., 60 mg immediate-release, 180 mg extended-release, or liquid) based on patient needs

To test if the cyclin D hydrophobic patch is required to properly form an active cyclin D-CDK4/6 complex in cells via the p27 assembly factor we used our cyclin D1 replacement system described above to knockdown the endogenous cyclin D1 and re-express different cyclin D1 variant proteins fused to a FLAG epitope tag

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