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+ T cell function is mainly manifested as antigen-specific loss and proliferation limitation resulting in low frequency, as well as high expression of inhibitory receptors such as programmed death-1 (PD-1), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), mucin domain-3 (TIM-3), etc

GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide originally found in human serum and shown to stimulate growth in hepatoma cells [1]

Nuclear factor-kappa B (NF-kB) has a significant role in inflammation and cell growth, which are both connected to the development of tumors (170, 171)