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A controlled clinical study

Assimilation of gaseous ammonia and the transport of its products in barley and spinach leaves

It is advisable to seek professional guidance before starting supplementation

Although there is still a lack of research on the specific mechanism of PH-targeting drugs regulating pulmonary vascular cell apoptosis, it is clear that among the three targeted therapy pathways, the nitric oxide pathway (e.g., phosphodiesterase 5 inhibitors) and prostacyclin pathway (e.g., prostacyclin receptor agonists) can promote the apoptosis of both PASMCs and PAECs to reverse pulmonary vessel wall thickening through the mitochondrial pathway and extrinsic pathway, respectively [43,44,45,46]