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Safety and effectiveness should be guaranteed by giving priority to customized biomarker-guided strategies

Within this paradigm, in vitro research is considered mechanistic, and hypothesis-generating, experimental in vivo research is translational, and field or applied veterinary research is considered the most suitable for clinically actionable findings

The shift in the composition of KCs from a pro-inflammatory phenotype (higher M1/M2 ratio) in the CDG group to a less inflammatory phenotype (lower M1/M2 ratio) in the CDVDG group likely contributed to the improved hepatic cytokine profile observed in the latter