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Mechanistically, calcitriol upregulates key lipid-synthesizing enzymesincluding fatty acid synthase (FAS), 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase), and serine palmitoyltransferase (SPT)and promotes lamellar body maturation and secretion, thereby enhancing stratum corneum structural cohesion [234,235,236]