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10.1039/d3ra03926a 65 DuL.WuY.JiaQ.LiJ.LiY.MaH.et al (2023)

VHL inactivation is an important pathway for the development of malignant sporadic pancreatic endocrine tumors

That includes signals tied to swelling, oxidative stress, and tissue breakdown

Consistent with these structural features, sequence alignment indicates that the key residues forming the ABCB7-CoPP interaction network are not well conserved in ABCB10 (Fig