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The mechanism through which Trx1 exhibits antioxidant activity is through inhibiting intracellular ROS levels, DNA fragmentation, and regulating apoptosis (Yeo et al., 2021)

Management of respiratory depression may include close observation, supportive measures, and use of opioid overdose reversal agents (e.g., naloxone, nalmefene), depending on the patients clinical status [see OVERDOSAGE]