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1.3 Supplier: BIONIX RESEARCH Email: [email protected] 1.4 Emergency: EU Emergency Number: 112 SECTION 2 Hazards Identification 2.1 Classification: Not classified as hazardous under CLP Regulation (EC) 1272/2008

By extracting aortic tissue from the mice and performing WB analysis, we found that the expression levels of P53 and FOXO4 were both elevated (Supplementary Figure S1A)