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TDP-43 exhibits rhythmic expression, and its knockdown disrupts circadian behavior, alters the expression of core clock genes including BMAL1, CLOCK, CRY1, and PER2, and weakens cognition and balancing abilities in mice ( TDP-43 knockdown induces aberrant splicing and downregulation of USP13, which in turn leads to increased ubiquitination and degradation of BMAL1

D.SontagM

Given the mere mass of malignant cells within a solid tumor such as HCC, we hypothesized that tumor targeting and efficient killing of tumor cells would require a stable expression of an HBV-specific TCR to allow T cells to expand while maintaining their specificity and effector function

Thorgersen, E