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Perhaps one of the most notable examples of autolytic proteolysis is the incidence of belly-bursting in pelagic (fatty fish) species such as herring and capelin

The metabolic product of PAHs, particularly BPDE, not only forms covalent adducts with DNA, resulting in genomic instability, but also regulates the expression of oncogenes and tumor suppressor genes through epigenetic mechanisms (Li et al., 2007

Clinical studies further support these findings, reporting mean maximum plasma concentrations (Cmax) of AS-IV at 2.12, 3.59, 3.71, and 5.17 g/mL following single doses of 200, 300, 400, and 500 mL of astragaloside injection (AI), respectively (Xu et al., 2013)